Atlas of Genetics and Cytogenetics in Oncology and Haematology CYR 61 ( cysteine - rich , angiogenic inducer , 61 )

Other names: CCN1, GIG1, IGFBP10 HGNC (Hugo): CYR61 Location: 1p22.3 Note CYR61 (cysteine-rich angiogenic inducer 61; also named CCN1), first identified as a serum-inducible immediate-early gene, encodes a secreted, extracellular matrix-associated protein that regulates diverse cellular functions (Lau, 2011). CYR61 and five later identified homologs comprise the six-member CCN family, named after the first three members described: CYR61, CTGF (connective tissue growth factor; CCN2), and NOV (nephroblastoma overexpressed; CCN3) (Jun and Lau, 2011). By international consensus, these genes have now been renamed CCN1-6 (Brigstock et al., 2003).